Multiple antidiabetic effects of three α-glucosidase inhibitory peptides, PFP, YPL and YPG: Dipeptidyl peptidase-IV inhibition, suppression of lipid accumulation in differentiated 3T3-L1 adipocytes and scavenging activity on methylglyoxal

Autor:	Anabella R.M. Gaspar, Albert W. H. Neitz, Mohammed Auwal Ibrahim, Megan Jean Bester, June C. Serem
Rok vydání:	2018
Předmět:	02 engineering and technology Biochemistry Dipeptidyl peptidase 03 medical and health sciences chemistry.chemical_compound Mice Structural Biology Adipocyte 3T3-L1 Cells Adipocytes Animals Humans Hypoglycemic Agents Glycoside Hydrolase Inhibitors Amino Acid Sequence Cytotoxicity Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species Dipeptidyl-Peptidase IV Inhibitors Methylglyoxal 3T3-L1 Cell Differentiation alpha-Glucosidases General Medicine Glutathione Free Radical Scavengers 021001 nanoscience & nanotechnology Lipid Metabolism Pyruvaldehyde In vitro Molecular Docking Simulation chemistry 0210 nano-technology Oligopeptides
Zdroj:	International journal of biological macromolecules. 122
ISSN:	1879-0003
Popis:	Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; dipeptidyl peptidase-IV inhibition (DPP-IV), lipid accumulation and the differentiation of 3T3-L1 adipocytes, and scavenging of methylglyoxal (MGO), reactive oxygen species (ROS) and nitric oxide (NO). The peptides were subjected to molecular docking on human DPP-IV where the binding free energies were PFP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fec09a0cc6bd689b5fae3884a0928d https://pubmed.ncbi.nlm.nih.gov/30365987 Zobrazit plný text záznamu Full Text from ScienceDirect