A transversal pilot study of oropharyngeal carriage of Kingella kingae in healthy children younger than 6 months
| Autor: | Sergio Manzano, Abdessalam Cherkaoui, Dimitri Ceroni, Vasiliki Spyropoulou, Gesuele Renzi, Jacques Schrenzel, Rebecca Anderson della Llana, Gabriel Brändle, Albane B.R. Maggio |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pediatrics Neisseriaceae Infections Oropharynx/microbiology 030106 microbiology Oropharynx Kingella kingae Pilot Projects Risk Assessment Carrier State/epidemiology/microbiology Young infants Cohort Studies 03 medical and health sciences Sex Factors Switzerland/epidemiology Sex factors Pediatric surgery Kingella kingae/isolation & purification Medicine Humans Prospective Studies Prospective cohort study ddc:616 ddc:618 biology business.industry Incidence (epidemiology) Incidence Infant Newborn Age Factors Infant biology.organism_classification Newborn Healthy Volunteers Carriage Pediatrics Perinatology and Child Health Carrier State Neisseriaceae Infections/diagnosis/epidemiology Female business Switzerland Cohort study |
| Zdroj: | World Journal of Pediatrics, Vol. 13, No 6 (2017) pp. 615-617 |
| ISSN: | 1708-8569 |
| Popis: | The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life.We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections.We demonstrated an oropharyngeal carriage rate of 0.67% in children younger than 6 months. Due to the really low carriage rate, it was not possible to draw statistically significant conclusion about any other characteristic of our population.The present study suggests that the oropharyngeal carriage of Kingella kingae among a Swiss population of healthy infants younger than 6 months is exceptional. The scarcity of colonization and disease in the early months of life suggests thus that defense against mucosal carriage and invasive infection is above all provided by vertically acquired immunity. Limited exposure of the neonates due to limited social contacts may also represent another factor avoiding neonates' mucosal Kingella kingae carriage. |
| Databáze: | OpenAIRE |
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