Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E2 and C-reactive protein in serum and livers of pregnant and non-pregnant female rats
| Autor: | Saura C. Sahu, P.P. Sapienza, Paddy Wiesenfeld, Thomas F.X. Collins, M.W. O'Donnell, C.E. Ford, Ivan A. Ross, Robert L. Sprando, Thomas J. Flynn, Chung S Kim |
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| Rok vydání: | 2006 |
| Předmět: |
Very low-density lipoprotein
medicine.medical_specialty medicine.medical_treatment Administration Oral Blood lipids Biology Toxicology Dinoprostone chemistry.chemical_compound Adenosine Triphosphate Pregnancy Internal medicine medicine Animals Lipolysis Androstenedione Prostaglandin E2 reproductive and urinary physiology Dose-Response Relationship Drug Caspase 3 Cholesterol Fatty Acids General Medicine Rats C-Reactive Protein Endocrinology Liver chemistry Docosahexaenoic acid Caspases Female Food Science medicine.drug Prostaglandin E |
| Zdroj: | Food and Chemical Toxicology. 44:579-587 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2005.09.005 |
| Popis: | Androstenedione, a steroidal dietary supplement taken to enhance athletic performance, could affect serum and liver lipid metabolism, induce liver toxicity or alter inflammatory response depending on dose and duration of exposure. Pregnancy could further exaggerate these effects. To examine this, mature female rats were gavaged with 0, 5, 30 or 60 mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60 mg/kg/day androstenedione. Serum was collected and livers were removed from dams on gestation day 20 and from non-pregnant rats after 5 weeks of treatment. Androstenedione had no effect on serum total cholesterol, triglycerides or HDL-cholesterol, but significantly decreased C-reactive protein in pregnant rats and prostaglandin E(2) in serum of both pregnant and non-pregnant rats. There were treatment related decreases in liver ATP and, to a lesser degree, caspase-3 and no change in alkaline phosphatase of pregnant female rats. Androstenedione decreased docosahexaenoic acid in both serum and liver phospholipids of pregnant female rats. In conclusion, oral androstenedione did not result in overt hepatotoxicity in pregnant female rats, but produced modest changes in lipid metabolism and may impair regeneration of injured hepatic cells or tissue. |
| Databáze: | OpenAIRE |
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