Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients
| Autor: | Kyu Hun Choi, Shin Wook Kang, Tae Hyun Yoo, Dong Ho Shin, Dae Suk Han, Dong Eun Yoo, Seung Hyeok Han, Seung Jun Kim, Mi Jung Lee, Hyung Jung Oh |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipokine Models Biological Body Mass Index Peritoneal dialysis chemistry.chemical_compound Endocrinology Insulin resistance Internal medicine medicine Homeostasis Humans Resistin Aged Adiponectin Triglyceride Interleukin-6 business.industry Cholesterol HDL nutritional and metabolic diseases Middle Aged medicine.disease C-Reactive Protein Cross-Sectional Studies chemistry Kidney Failure Chronic Female Insulin Resistance business Peritoneal Dialysis Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Journal. 59:685-695 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej12-0032 |
| Popis: | In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI)25 kg/m(2). IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m(2). When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD. |
| Databáze: | OpenAIRE |
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