Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids
| Autor: | Zdravko Sumic, N Aleksandra Tepic, O Sanja Podunavac-Kuzmanovic, R Lidija Jevric |
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| Rok vydání: | 2013 |
| Předmět: |
RP HPLC
Paprika oleoresin General Chemical Engineering Chemical structure 02 engineering and technology lcsh:Chemical technology 01 natural sciences chemistry.chemical_compound QSRR Molecular descriptor Phase (matter) lipophilicity Acetone lcsh:TP1-1185 Carotenoid chemistry.chemical_classification Chromatography 010401 analytical chemistry carotenoids General Chemistry Reversed-phase chromatography 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Lipophilicity 0210 nano-technology |
| Zdroj: | Hemijska Industrija, Vol 67, Iss 6, Pp 933-940 (2013) Hemijska industrija (2013) 67(6):933-940 |
| ISSN: | 2217-7426 0367-598X |
| Popis: | Influence of chemical structure on the lipophilicity of isolated free carotenoids from paprika oleoresin has been studied by QSRR approach (Quantitative structure-retention relationship). The chromatographic behavior of these compounds was investigated by using reversed phase high-pressure liquid chromatography (RP HPLC). Retention mechanism has been determined using the following mobile phase: acetone -water, on reversed - phase column (SB-C18). A variety of lipophilicity parameters (logP) were calculated by use of different software products. On the basis of correlations, the nonlinear structure-activity models were derived between the retention constants, tr (retention time of investigation compounds), and logP values. Five high quality QSRR models were found to have a good predictive ability and close agreement between experimental and predicted values. The study showed that the retention constants can be used as a measure of lipophilicity of investigated compounds at a high significant level. [Projekat Ministarstva nauke Republike Srbije, br. 172012, br. 172014 i br. 31055] |
| Databáze: | OpenAIRE |
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