GH Treatment Induces Sustained Catch-Up Growth in Children with Intrauterine Growth Retardation: 7-Year Results
| Autor: | Assunta Albanese, R. Stanhope |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Aging medicine.medical_specialty Fetal Growth Retardation Growth retardation business.industry Endocrinology Diabetes and Metabolism Infant Growth Short stature Body Height Growth hormone treatment Endocrinology Child Preschool Growth Hormone Internal medicine medicine Gh treatment Humans Female medicine.symptom Child business |
| Zdroj: | Hormone Research. 48:173-177 |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000185509 |
| Popis: | The anthropometric response to 7 years of GH treatment was assessed in 11 short children with Russell-Silver syndrome (RSS) and in 5 with non-dysmorphic intrauterine growth retardation (NRSS). GH treatment induced a significant increase (p0.0001) in the mean height standard deviation score (SDS) and at the 7-year follow-up a height appropriate for the natural history of final stature in NRSS/RSS was already attained. An appreciable growth rate was still present with final height being attained only in 2 girls. There was no significant change in height SDS for bone age. Multiple regression analysis showed only chronological age at the onset of GH treatment was a predictor of gain in height SDS during GH therapy. These findings suggest that early GH treatment improves long-term growth in children with NRSS/RSS. Moreover, final height attainment is required for a definitive assessment of the beneficial effect on adult stature. Bone age assessment is not a reliable parameter to predict final height outcome in these children. |
| Databáze: | OpenAIRE |
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