Classification of skin sensitizing substances: a comparison between approaches used by the DFG-MAK Commission and the European Union legislation
| Autor: | Wolfgang Uter, Hans Drexler, Andrea Hartwig, Axel Rothe, P. Kreis, Axel Schnuch, Thomas L. Diepgen, Manigé Fartasch, Dennis Nowak, H. Greim, Hans F. Merk, E. Löser, G. Stropp, Rolf Merget, Holger Lessmann |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Internationality Respiratory System Legislation Guidelines as Topic Commission Toxicology Dermatitis Contact Occupational safety and health Hazardous Substances 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Pregnancy Environmental health Germany Occupational Exposure Toxicity Tests media_common.cataloged_instance Medicine Humans European Union European union Workplace media_common Skin business.industry Skin sensitization General Medicine 030210 environmental & occupational health 3. Good health Systemic toxicity Female Occupational exposure business Cutaneous absorption |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 61(1) |
| ISSN: | 1096-0295 |
| Popis: | A systematic classification of substances (or mixtures of substances) with regard to various toxicological endpoints is a prerequisite for the implementation of occupational safety strategies. As its principal task the "Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area" of the "Deutsche Forschungsgemeinschaft" (DFG-MAK Commission) derives and recommends maximum workplace concentrations and biological tolerance values (MAK and BAT values) based exclusively on scientific arguments. Several endpoints are evaluated separately in detail, e.g. carcinogenicity, risks during pregnancy, germ cell mutagenicity or contribution to systemic toxicity after cutaneous absorption. Skin- and airway sensitization is also considered; the present paper focuses on these two endpoints. |
| Databáze: | OpenAIRE |
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