Myelin biomarkers in the healthy adult brain: Correlation, reproducibility, and the effect of fiber orientation

Autor: Sarah R. Morris, Irene M. Vavasour, Anastasia Smolina, Erin L. MacMillan, Guillaume Gilbert, Michelle Lam, Piotr Kozlowski, Carl A. Michal, Alan Manning, Alex L. MacKay, Cornelia Laule
Rok vydání: 2022
Předmět:
Zdroj: Magnetic Resonance in Medicine. 89:1809-1824
ISSN: 1522-2594
0740-3194
DOI: 10.1002/mrm.29552
Popis: We investigated the correlation, reproducibility, and effect of white matter fiber orientation for three myelin-sensitive MRI techniques: magnetization transfer ratio (MTR), inhomogeneous magnetization transfer ratio (ihMTR), and gradient and spin echo-derived myelin water fraction (MWF).We measured the three metrics in 17 white and three deep grey matter regions in 17 healthy adults at 3 T.We found a strong correlation between ihMTR and MTR (r = 0.70, p 0.001) and ihMTR and MWF (r = 0.79, p 0.001), and a weaker correlation between MTR and MWF (r = 0.54, p 0.001). The dynamic range in white matter was greatest for MWF (2.0%-27.5%), followed by MTR (14.4%-23.2%) and then ihMTR (1.2%-5.4%). The average scan-rescan coefficient of variation for white matter regions was 0.6% MTR, 0.3% ihMTR, and 0.7% MWF in metric units; however, when adjusted by the dynamic range, these became 6.3%, 6.1% and 2.8%, respectively. All three metrics varied with fiber direction: MWF and ihMTR were lower in white matter fibers perpendicular to BThe strong correlation between ihMTR and MWF suggests that these techniques are measuring the same myelination; however, the larger dynamic range of MWF may provide more power to detect small differences in myelin.
Databáze: OpenAIRE
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