Microbial transformation of the anti-diabetic agent corosolic acid
| Autor: | Zhi-Yong Chu, Dai-Ping Li, Ze-Sheng Zhang, Xu Feng, Luan Jie |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
Metabolite Plant Science DEPT Biochemistry Streptomyces Analytical Chemistry Terpene chemistry.chemical_compound Biotransformation Ascomycota Diabetes Mellitus Hypoglycemic Agents Glycoside Hydrolase Inhibitors Nuclear Magnetic Resonance Biomolecular biology Molecular Structure Organic Chemistry alpha-Glucosidases Carbon-13 NMR Cochliobolus lunatus biology.organism_classification Triterpenes chemistry Corosolic acid |
| Zdroj: | Natural product research. 28(21) |
| ISSN: | 1478-6427 |
| Popis: | Biotransformation of corosolic acid (1) by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites, which were identified by using 1H NMR, 13C NMR, DEPT, HSQC, HMBC and NOESY spectral data. Biotransformation of corosolic acid by C. lunatus R.R. Nelson & Haasis CGMCC 3.4381 produced three metabolites: 2α,3β,21β-trihydroxyurs-12-en-28-oic acid (2), 2α,3β,7β,21β-tetrahydroxy-urs-12-en-28-oic acid (3) and 2α,3β-dihydroxy-21-oxours-12-en-28-oic acid (4). Incubation of corosolic acid with growing cultures of S. asparaginoviolaceus CGMCC 4.0175 afforded metabolite 2α,3β,30-trihydroxyurs-12-en-28-oic acid (5). All the metabolites were reported for the first time. The substrate and four metabolites, along with four products obtained previously, were evaluated for their inhibitory effects on α-glucosidase; all the triterpenes tested showed potent inhibitory effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|