Inflammatory/oxidative stress during the first week after different types of cardiac surgery

Autor:	Günter Taal, Inga Karu, Chris Pruunsild, Joel Starkopf, Kersti Zilmer, Mihkel Zilmer
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Time Factors Homocysteine Arginine law.invention Coronary artery disease chemistry.chemical_compound Aortic valve replacement law Internal medicine medicine Cardiopulmonary bypass Humans Cardiac Surgical Procedures Coronary Artery Bypass Aged Peroxidase Heart Valve Prosthesis Implantation Inflammation Cardiopulmonary Bypass biology Interleukin-6 business.industry C-reactive protein Middle Aged medicine.disease Cardiac surgery Oxidative Stress C-Reactive Protein Treatment Outcome medicine.anatomical_structure chemistry Cardiology biology.protein Female Inflammation Mediators Cardiology and Cardiovascular Medicine business Asymmetric dimethylarginine Biomarkers Artery
Zdroj:	Scandinavian Cardiovascular Journal. 44:119-124
ISSN:	1651-2006 1401-7431
Popis:	To compare inflammatory and oxidative stress time course during the first week after different types of cardiac surgery.In patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (CABG) or on the working heart (OPCAB) and aortic valve replacement (VALVE) blood samples for high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), myeloperoxidase (MPO), asymmetric dimethylarginine (ADMA) and homocysteine (Hcy) were taken preoperatively and for six consecutive postoperative days.Exploitation of cardiopulmonary bypass (CABG, VALVE groups), but not OPCAB, resulted in significant rise of MPO for two postoperative days. ADMA and Hcy changed in parallel fashion, being significantly decreased in the first postoperative morning and rising to the preoperative levels thereafter. In comparison with coronary artery disease patients, VALVE group had lower preoperative levels of ADMA and different postoperative time course. Postoperative concentrations of IL-6 and hsCRP were increased significantly in all groups and remained elevated during the first postoperative week.Cardiac surgery results in extensive and complex inflammatory/oxidative stress response regardless of the method or type of surgical procedure used. Myeloperoxidase could be one of the parameters to evaluate the cardiopulmonary bypass-associated inflammatory and oxidative stress response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f6302f52d4e14c78ab21a44324e509 https://doi.org/10.3109/14017430903490981 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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