Impact of HIV infection on cardiac deformation
| Autor: | Carla Paixão Miranda, Leonel Bernardino, Paula Brito, Nelson Duarte, José Poças, Joana Sá, Lígia Mendes, Luís Duque, Daniela Cristina de Oliveira Silva |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Population Diastole HIV Infections Doppler imaging Asymptomatic Ventricular Function Left Ventricular Dysfunction Left Basal (phylogenetics) Internal medicine medicine Humans education Asymptomatic Infections General Environmental Science education.field_of_study Strain (chemistry) business.industry Middle Aged Viral Load Strain rate Echocardiography Doppler CD4 Lymphocyte Count Surgery lcsh:RC666-701 Case-Control Studies Cardiology General Earth and Planetary Sciences Female medicine.symptom Cardiology and Cardiovascular Medicine business Viral load |
| Zdroj: | Revista Portuguesa de Cardiologia, Vol 33, Iss 9, Pp 501-509 (2014) Revista Portuguesa de Cardiologia (English Edition), Vol 33, Iss 9, Pp 501-509 (2014) |
| ISSN: | 0870-2551 |
| DOI: | 10.1016/j.repc.2013.12.006 |
| Popis: | Aim: The aim of this study was to detect abnormalities in left ventricular myocardial function due to HIV (human immunodeficiency virus) infection without established cardiovascular disease. Methods: An echocardiogram was performed in 50 asymptomatic HIV-infected patients (age 41±6 years, 64% male) and in 20 healthy individuals. Conventional echocardiography and pulsed tissue Doppler imaging (TDI) were performed according to the guidelines. The strain rate of the basal segments was obtained with color tissue Doppler and used to evaluate systolic strain rate (SRS), early diastolic strain rate (SRE) and late diastolic strain rate (SRA). Longitudinal, radial and circumferential strain were assessed by 2D speckle tracking. Results: The mean duration of HIV infection was 10±5 years, CD4 count was 579±286 cells/mm3, 32% had detectable viral load, and 86% were under treatment. Of the HIV-infected patients, one had grade 1 diastolic dysfunction. The groups were not different except for E wave (HIV 0.72±0.17 m/s vs. control 0.84±0.16 m/s, p=0.01), longitudinal strain (−19.5±1.9% vs. −21±2%, p=0.005), SRS (−1.1±0.28 s−1 vs. −1.3±0.28 s−1, p=0.02) and SRE (1.8±0.4 s−1 vs. 2.2±0.4 s−1, p |
| Databáze: | OpenAIRE |
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