Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
| Autor: | Sarah R. Amend, Emma U. Hammarlund, Robert Axelrod, Kenneth J. Pienta, Joel S. Brown, Robert H. Austin |
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| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Cancer Research Biology Genome Cancer recurrence Polyploidy 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Humans Lethal cancer Cell Nucleus Chromatin/genetics Cell Enlargement Cancer Therapeutic resistance medicine.disease Neoplasms/genetics Chromatin Cell biology Cell and molecular biology Whole genome doubling 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Polyploid giant cancer cells Convergent evolution |
| Zdroj: | Pienta, K J, Hammarlund, E U, Austin, R H, Axelrod, R, Brown, J S & Amend, S R 2022, ' Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy ', Seminars in Cancer Biology, vol. 81, pp. 145-159 . https://doi.org/10.1016/j.semcancer.2020.11.016 |
| ISSN: | 1044-579X |
| Popis: | Unusually large cancer cells with abnormal nuclei have been documented in the cancer literature since 1858. For more than 100 years, they have been generally disregarded as irreversibly senescent or dying cells, too morphologically misshapen and chromatin too disorganized to be functional. Cell enlargement, accompanied by whole genome doubling or more, is observed across organisms, often associated with mitigation strategies against environmental change, severe stress, or the lack of nutrients. Our comparison of the mechanisms for polyploidization in other organisms and non-transformed tissues suggest that cancer cells draw from a conserved program for their survival, utilizing whole genome doubling and pausing proliferation to survive stress. These polyaneuploid cancer cells (PACCs) are the source of therapeutic resistance, responsible for cancer recurrence and, ultimately, cancer lethality. |
| Databáze: | OpenAIRE |
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