Trabecular Bone Score (TBS) and Bone Metabolism in Patients Affected with Type 1 Neurofibromatosis (NF1)
| Autor: | Uberta Verga, Federica Natacci, Giulia Rodari, Claudia Giavoli, Marcello Filopanti, Maura Arosio, Anna Spada, Fabio Massimo Ulivieri |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin Adult Male medicine.medical_specialty Neurofibromatosis 1 Endocrinology Diabetes and Metabolism medicine.medical_treatment Urology 030209 endocrinology & metabolism Bone and Bones Bone remodeling Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Trabecular bone score Bone Density Vitamin D and neurology Medicine Humans Orthopedics and Sports Medicine Neurofibromatosis Reduction (orthopedic surgery) business.industry Middle Aged medicine.disease chemistry Case-Control Studies Cohort Orthopedic surgery Cancellous Bone Disease Progression Osteoporosis Female 030101 anatomy & morphology Bone Remodeling business |
| Zdroj: | Calcified tissue international. 104(2) |
| ISSN: | 1432-0827 |
| Popis: | In patients with neurofibromatosis type 1 (NF1), decreased bone mineral density (BMD) and low levels of 25-hydroxy vitamin D3 (25OHD) have been reported. Recently, the trabecular bone score (TBS) measurement has been proposed as index of bone microarchitecture and fracture risk. In 74 NF1 patients (48 females, 26 males, age 41 ± 12), we measured TBS and investigated clinical stage, lifestyle, vitamin D, serum bone turnover markers, vertebral and femoral BMD. A homogenous cohort of 61 healthy subjects was used as control group. TBS was lower in NF1 patients (1.266 ± 0.113 vs. 1.346 ± 0.105) without differences between sexes. No correlations with 25OHD, low exercise, low calcium intake, reduced sun exposure, and number of skin neurofibromas were observed. As expected, hypovitaminosis D was common (98.6%), as well as BMD reduction in hip and spine sites: In NF1 patients, bone texture evaluated by TBS was low in both sexes without any correlation with clinical or metabolic parameters, suggesting a direct role of the fibromin mutation. |
| Databáze: | OpenAIRE |
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