Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London
| Autor: | Richard Sullivan, Saoirse Dolly, Gincy George, Piers E.M. Patten, Kieran Palmer, Elinor J. Sawyer, Andrea D'Souza, James Spicer, Simon Gomberg, Reuben Benjamin, Paul Ross, Kamarul Zaki, Anna Haire, Ailsa Sita-Lumsden, Austin G. Kulasekararaj, Sophie Papa, Fidelma Cahill, Muhammed Mansour Ceesay, Victoria Potter, Sheeba Irshad, Thinzar Ko Ko, Mieke Van Hemelrijck, Beth Russell, Debra H. Josephs, Claire N. Harrison, Paul Fields, Danielle Crawley, Antonio Pagliuca, Vallari Shah, Deborah Enting, Rushan Sylva, Angela Swampillai, Harriet Wylie, Charlotte Moss, Anne Rigg, David Wrench, Shahram Kordasti, Maria J. Monroy-Iglesias |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Patient characteristics Article Internal medicine Neoplasms Cox proportional hazards regression Cancer centre London medicine Humans Aged Aged 80 and over business.industry SARS-CoV-2 Cancer COVID-19 Translational research Middle Aged medicine.disease Hospitals Risk factors Oncology Raised CRP Hematologic Neoplasms Haematological cancer Female business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death. Methods Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality. Results Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died 2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients ( Conclusions Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink