Glycogen content of tissue culture fibroblasts from patients with cystic fibrosis and other heritable disorders
| Autor: | Ulrich Wiesmann, J. Charles Pallavicini, William B. Uhlendorf, Paul A. di Sant' Agnese |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Electrophoresis
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pathology Time Factors Cystic Fibrosis Glucose uptake Cytoplasmic Granules Cystic fibrosis Cell Line Normal cell Tissue culture chemistry.chemical_compound Culture Techniques Internal medicine medicine Humans Glycogen storage disease Skin Starvation Metaplasia Glycogen business.industry Diffuse Cerebral Sclerosis of Schilder Fibroblasts medicine.disease Culture Media Endocrinology chemistry Cell culture Pediatrics Perinatology and Child Health medicine.symptom business Gels Carbohydrate Metabolism Inborn Errors |
| Zdroj: | The Journal of Pediatrics. 77:280-284 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(70)80336-5 |
| Popis: | Skin fibroblasts from patients with cystic fibrosis, some patients with mucopolysaccharidoses, and normal subjects were cultured for various lengths of time. Cystic fibrosis fibroblasts showed a significantly higher glycogen content than the normal cell lines. Since in starvation experiments all cell lines lost their glycogen at comparably fast rates, and cystic fibrosis is not considered to be a glycogen storage disease, it is possible that in cultured cystic fibrosis fibroblasts an increased glucose uptake occurs. |
| Databáze: | OpenAIRE |
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