Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers
| Autor: | Monica Lamberti, Marina Di Domenico, Elpidio Maria Garzillo, Stefania Porto, Vincenzo Tombolini, Franca Avino, Giancarlo Giovane, Antonia Feola |
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| Přispěvatelé: | Lamberti, Monica, Giovane, G, Garzillo, Em, Avino, F, Feola, A, Porto, S, Tombolini, V, DI DOMENICO, Marina, Lamberti, M., Giovane, G., Garzillo, E. M., Avino, F., Feola, A., Porto, S., Tombolini, V., Di Domenico, M. |
| Rok vydání: | 2014 |
| Předmět: |
Side effect
lcsh:Medicine Antineoplastic Agents Apoptosis Review Article Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Cyclopentenyl Cytosine Antineoplastic Agent Mice In vivo Trastuzumab medicine Animals Humans Cytotoxic T cell Cardiotoxicity General Immunology and Microbiology Animal business.industry lcsh:R Apoptosi Heart General Medicine Rats Oxidative Stress Models Animal Rat business Oxidative stress Human medicine.drug |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2014/240642 |
| Popis: | Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models. |
| Databáze: | OpenAIRE |
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