Concurrencia de síndromes paraneoplásicos neurológicos, en paciente afecta de cáncer de mama y metástasis cerebral: revisión de la literatura
| Autor: | J. Fuentes-Pradera, A. L. Moreno-Vega, E. Jiménez-Orozco, S. Flores-Prieto, I. Fernández-Cantón, J. M. Girón-Úbeda |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Síndrome Paraneoplásico neurológico Adjuvant chemotherapy business.industry medicine.medical_treatment Limbic encephalitis medicine.disease Radiation therapy Clinical trial Anticuerpos onconeuronales Breast cancer Cáncer de mama Internal medicine Encefalítis límbica Carcinoma medicine Síndrome Eaton-Lambert Quimioterapia business Irreversible Coma Mastectomy |
| Zdroj: | Oncología (Barcelona) v.29 n.2 2006 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname |
| Popis: | Neurological paraneoplastic syndromes are complex entities of difficult diagnosis. They can locate in any part of the nervous system producing important neurological dysfunctions. The discovery of new specific anti-neuronal antibodies and their relation with the associated immunological alterations help to make an early diagnosis. Association with breast cancer is not frequent. We present the case of a 62-year old patient with left breast carcinoma that had been treated by mastectomy and adjuvant chemotherapy one year before. She relapsed with cerebellum metastases and was treated by surgery and radiotherapy. The picture was complicated with a Lambert-Eaton-like myasthenic syndrome, neuroplastic sensory neuronopathy, limbic encephalitis and irreversible coma. The application of new diagnostic criteria, the molecular discoveries and the performance of therapeutic clinical trials could better the life expectancy of these patients. |
| Databáze: | OpenAIRE |
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