Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines
| Autor: | Mitchell H. Keylor, Zachary L. Niemeyer, Matthew S. Sigman, Kian L. Tan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Ligand General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Chloride Catalysis 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Ferrocene chemistry medicine Surface modification Organic chemistry Amine gas treating Chemoselectivity Amination medicine.drug |
| Zdroj: | Journal of the American Chemical Society. 139(31) |
| ISSN: | 1520-5126 |
| Popis: | A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bis[bis(dimethylamino)phosphino]ferrocene “DMAPF”, a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation. |
| Databáze: | OpenAIRE |
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