Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs
| Autor: | Ray F. Nachreiner, Louis G. D'Alecy, Gilbert H. Mayor, Matthew A. Facktor |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty Resuscitation Time Factors Emergency Nursing chemistry.chemical_compound Dogs Internal medicine Blood plasma medicine Animals Triiodothyronine business.industry Thyroid medicine.disease Cardiopulmonary Resuscitation Euthyroid Sick Syndromes Reverse triiodothyronine Heart Arrest Thyroxine Endocrinology medicine.anatomical_structure chemistry Ventricular Fibrillation Ventricular fibrillation Emergency Medicine Cardiology and Cardiovascular Medicine business Levothyroxine Sodium Euthyroid sick syndrome |
| Zdroj: | Resuscitation. 26:141-162 |
| ISSN: | 0300-9572 |
| Popis: | Circulating concentrations of thyroxine (T4), triiodothyronine (T3), and reverse triiodothyronine (rT3) were followed in dogs subjected to 9 min of normothermic ventricular fibrillation. Significant decreases were detected 12 h post-arrest when compared to pre-arrest levels in total T4 (P0.0005), free T4 (P0.0005), total T3 (P0.003), and free T3 (P0.003), and levels of reverse T3 were significantly elevated (P = 0.0001). Similar changes occurred with only 30 s of arrest. Post-arrest replacement therapy with 7.5 micrograms/kg per h (Rx-7.5) and 15 micrograms/kg per h (Rx-15) levothyroxine sodium (L-T4) increased total T4, free T4, and total T3 (P0.01). Free T3 decreased in the Rx-7.5 group (P0.01) and did not fall in the Rx-15 group (P = 0.16). Reverse T3 increased with either treatment (P0.005). Both treatment groups had higher levels of all five hormones than non-treated animals (P0.001). Neurologic function, assessed with a standardized scoring system, showed significant improvement in the treated groups by 6 h (P0.05, compared to non-treated group) and remained significant through 24 h post-arrest (P0.05). The documentation of rapid and dramatic changes in thyroid hormones immediately following cardiac arrest and resuscitation indicates a significant acute hypothyroid state that may potentially benefit from replacement therapy. |
| Databáze: | OpenAIRE |
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