The effect of BCG on in vitro immune reactivity and clinical course in dogs treated surgically for osteosarcoma
| Autor: | John S. Reif, Isaiah J. Fidler, Robert S. Brodey, Steen Bech-Nielsen, Donald A. Abt |
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| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Antibodies Neoplasm Binding Competitive Gastroenterology Metastasis Leukocyte Count Dogs Internal medicine Animals Medicine Lymphocytes Neoplasm Metastasis Survival rate Immunity Cellular Osteosarcoma business.industry Clinical course General Medicine medicine.disease Mycobacterium bovis In vitro Cell mediated immunity Surgery BCG Vaccine Immune reactivity Female Sarcoma Experimental business Median survival |
| Zdroj: | European Journal of Cancer (1965). 13:33-41 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(77)90227-4 |
| Popis: | Cell mediated reactivity (CMR) and serum blocking activity (SBA) were assessed postsurgically in 11 dogs treated surgically for osteosarcoma. Six dogs received Bacillus Calmette-Guerin (BCG) and 5 served as controls. SBA decreased significantly soon after surgery in both groups. Two to three months after surgery SBA was slightly higher in the controls than in the BCG group. However, the postsurgical SBA in BCG recipients rose to about the same level as in the controls at 4–12 months, correlating in time with radiographic appearance of metastasis. This suggested that BCG delayed SBA for several months. The median survival time of the BCG treated dogs was 40 weeks, significantly longer than the 13 week median survival time in the control group. The cumulative life table method for estimation of survival rate failed to show an effect of BCG on survival. |
| Databáze: | OpenAIRE |
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