ANTIACETYLCHOLINE ACTION OF IMIPRAMINE
| Autor: | P.K. Lahiri, Satish Arora |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
Imipramine medicine.medical_specialty medicine.medical_treatment Guinea Pigs Neuromuscular Junction Blood Pressure In Vitro Techniques Pharmacology chemistry.chemical_compound Dogs Vas Deferens Internal medicine Muscarinic acetylcholine receptor medicine Animals Neurotransmitter Uterus Heart Muscle Smooth Acetylcholine Rats Intestines Stimulant Autonomic nervous system Nicotinic agonist Endocrinology chemistry Cats Female Ganglia Rabbits Anura Histamine Muscle Contraction medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 18:509-513 |
| ISSN: | 0021-5198 |
| Popis: | Imipramine, a potent antidepressive drug has been shown to antagonize the actions of a number of autopharmacological substances like histamine, 5-hydroxytryptamine, bradykinin, catecholamines and acetylcholine (1). Sigg and his coworkers (2, 3) observed a dual effect of imipramine on the various manifestations of the autonomic nervous system; a blocking action at higher dosage and a stimulant effect with low concentrations. The purpose of the present study was to investigate in more details the interactions between imipramine and acetylcholine at various sites, where acetylcholine is the neurotransmitter. This was done both at the muscarinic and nicotinic site. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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