Population structure and virulence gene profiles of Streptococcus agalactiae collected from different hosts worldwide
| Autor: | Walter Regli, Maria del Pilar Crespo-Ortiz, Michael Zschöck, Christa Ewers, Margaret Ip, Roger Stephan, Sophia Johler, Julian Reyes-Velez, Sarah Schmitt, Revathi Gunturu, Marina Morach, Claudia Daubenberger, Margaret Crumlish, Urs Gilli |
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| Rok vydání: | 2017 |
| Předmět: |
DNA
Bacterial 0301 basic medicine Microbiology (medical) medicine.medical_specialty Swine 030106 microbiology Population structure Virulence Biology medicine.disease_cause Streptococcus agalactiae Microbiology Bacterial genetics 03 medical and health sciences Dogs Medical microbiology Bacterial Proteins Streptococcal Infections medicine Animals Humans Animal species Gene Oligonucleotide Array Sequence Analysis Genetics General Medicine Infectious Diseases Cattle DNA microarray |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 37:527-536 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-017-3146-x |
| Popis: | Streptococcus agalactiae is a leading cause of morbidity and mortality among neonates and causes severe infections in pregnant women and nonpregnant predisposed adults, in addition to various animal species worldwide. Still, information on the population structure of S. agalactiae and the geographical distribution of different clones is limited. Further data are urgently needed to identify particularly successful clones and obtain insights into possible routes of transmission within one host species and across species borders. We aimed to determine the population structure and virulence gene profiles of S. agalactiae strains from a diverse set of sources and geographical origins. To this end, 373 S. agalactiae isolates obtained from humans and animals from five different continents were typed by DNA microarray profiling. A total of 242 different S. agalactiae strains were identified and further analyzed. Particularly successful clonal lineages, hybridization patterns, and strains were identified that were spread across different continents and/or were present in more than one host species. In particular, several strains were detected in both humans and cattle, and several canine strains were also detected in samples from human, bovine, and porcine hosts. The findings of our study suggest that although S. agalactiae is well adapted to various hosts including humans, cattle, dogs, rodents, and fish, interspecies transmission is possible and occurs between humans and cows, dogs, and rabbits. The virulence and resistance gene profiles presented enable new insights into interspecies transmission and make a crucial contribution to the identification of suitable targets for therapeutic agents and vaccines. |
| Databáze: | OpenAIRE |
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