Development and characterization of multiple emulsions for controlled release ofTrichilia catigua(Catuaba) extract
| Autor: | Francine B. Guimarães, João Carlos Palazzo de Mello, Gisely Cristiny Lopes, Eneri Vieira de Souza Leite-Mello, Maria Raquel Marçal Natali, Mariana Volpato Junqueira, Rafaela Said dos Santos, Audrey Alesandra Stinghen Garcia Lonni, Ieda Spacino Scarminio, Renata Longhini, Marcos Luciano Bruschi, Mauro Luciano Baesso, Fernanda Belincanta Borghi-Pangoni, Vanessa Marquito Munhoz |
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| Rok vydání: | 2015 |
| Předmět: |
Thixotropy
Antioxidant Swine Chemistry Pharmaceutical Skin Absorption medicine.medical_treatment Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Antioxidants Permeability 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Stability medicine Animals Plant Oils Phenol Meliaceae Particle Size Skin Chromatography biology Rheometry Catuaba Water General Medicine Permeation 021001 nanoscience & nanotechnology biology.organism_classification Controlled release Drug Liberation chemistry Delayed-Action Preparations Emulsions Rapeseed Oil Rheology 0210 nano-technology Trichilia catigua medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. 21:933-942 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | Considering the antioxidant activity of the Trichilia catigua extract (TCE), the aim of the current study was to develop and characterize W/O/W multiple emulsions containing different vegetable oils as a platform to deliver a TCE. The extract displayed antioxidant activity (IC50) of 4.59 µg/mL and total phenol content (TPC) of 50.84%. Formulations were prepared by the phase-inversion emulsification method and analyzed for morphological appearance, pH, conductivity, droplet size and distribution, content of active, rheological properties, in vitro release, skin permeation, and stability. Formulations prepared with canola oil were selected and displayed regular morphology, mean diameter 2.77 µm (without TCE), 3.07 µm with 0.5% and 3.23 µm with 1.0% TCE. Rheometry (flow) showed pseudoplastic behavior with minimal thixotropy for both systems. TCE could be released from emulsions containing 1.0% and 0.5% TCE in a controlled manner for 16 and 23 h, respectively. The emulsions allowed good retention of T... |
| Databáze: | OpenAIRE |
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