Effects of prophylactic swallowing exercises on dysphagia and quality of life in patients with head and neck cancer receiving (chemo) radiotherapy: the Redyor study, a protocol for a randomized clinical trial

Autor: Neus Bofill Soler, Ester Marco, Oscar Pera-Cegarra, Anna Guillén-Solà, Palmira Foro
Jazyk: angličtina
Rok vydání: 2019
Předmět:
EAT 10
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Medicine (miscellaneous)
law.invention
Study Protocol
03 medical and health sciences
0302 clinical medicine
Swallowing
Quality of life
Randomized controlled trial
law
Intervention (counseling)
medicine
otorhinolaryngologic diseases
Humans
Single-Blind Method
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
Randomized Controlled Trials as Topic
lcsh:R5-920
Rehabilitation
Head and neck cancer patients
business.industry
Head and neck cancer
Chemoradiotherapy
medicine.disease
Dysphagia
Deglutition disorders
Exercise Therapy
Deglutition
Treatment Outcome
Head and Neck Neoplasms
Spain
Quality of Life
Physical therapy
medicine.symptom
business
lcsh:Medicine (General)
030217 neurology & neurosurgery
Zdroj: Trials, Vol 20, Iss 1, Pp 1-7 (2019)
Trials
ISSN: 1745-6215
DOI: 10.1186/s13063-019-3587-x
Popis: Background: Squamous carcinoma of the head and neck (HNC) has a high incidence in our context. Although therapeutic radiotherapy protocols try to preserve swallowing function and essential speech organs, dysphagia is a frequent symptom in the acute and long-term phases, due to the toxic effects of therapies needed to confront the illness. Some studies have shown prophylactic oropharyngeal exercises to be quite useful in improving swallowing function after completion of chemo-radiation therapy (CRT) protocols; others have focused on their use to prevent or minimize post-CRT swallowing dysfunction. Patients’ quality of life deteriorates greatly during CRT, with a peak of maximum intensity during the days immediately after finishing CRT treatment. Afterwards, function gradually improves, although scope or timeframe remains undetermined. Available evidence suggests that exercise therapy prior to oncological treatment could potentially improve deglutition and quality of life; however, a randomized study is needed to confirm this observation. Design/Methods: The Redyor singe-blind randomized clinical trial is designed to compare the effect of prophylactic oropharyngeal exercises on quality of life, dysphagia, and sustainability to the length of rehabilitative treatment. At enrollment, participants will be randomly assigned to one of two treatment groups. Both groups follow the protocol described here, although one group begins the training 2 weeks before initiating CRT and the other group just after finishing the therapy. Both groups will complete standard swallow therapy for training submental muscles involved and 3 sets of 5 inspiratory and expiratory repetitions using the Orygen Dual® valve, with a progressive weekly increase in workload. Discussion: This ongoing clinical trial, registered in 2016, is based on the hypothesis that undergoing a pre-radiotherapy rehabilitation (pre-habilitation) program will have greater benefits (less decrease in quality of life, less delay in swallowing parameters, and less severe dysphagia) compared to post-CRT rehabilitation. The primary objective is to assess dysphagia severity and evaluate quality of life due to swallowing dysfunction in HNC patients. Secondary objectives are to assess the correlation between a clinical variable and instrumental parameters in this period
Databáze: OpenAIRE
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