Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
| Autor: | Dorothée Bouron-Dal Soglio, Sylvie Girard, Alexander E. P. Heazell, Dina El Demellawy, Solenn Dal Soglio, Kate Widdows, Marie-Eve Brien, Didier Menzies, Youssef Nasr, Camille Couture, Isabelle Boucoiran, Megan C. Sharps |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Canada Placenta Diseases Adolescent Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Placenta Psychological Distress Article Cohort Studies Young Adult Pregnancy Pandemic medicine Maternal fetal Humans Pregnancy Complications Infectious Pathological Pandemics Obstetrics Chorangiosis business.industry SARS-CoV-2 Incidence (epidemiology) Infant Newborn Pregnancy Outcome Obstetrics and Gynecology COVID-19 Middle Aged medicine.disease Infectious Disease Transmission Vertical United Kingdom Coronavirus disease 2019 (COVID-19) medicine.anatomical_structure Reproductive Medicine Case-Control Studies Maternal-Fetal Relations Female France business Infection Pandemic stress Stress Psychological Developmental Biology |
| Zdroj: | Placenta Brien, M-E, Bouron-Dal Soglio, D, Dal Soglio, S, Couture, C, Boucoiran, I, Nasr, Y, Widdows, K, Sharps, M, El Demellawy, D, Heazell, A, Menzies, D & Girard, S 2021, ' Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface ', Placenta . https://doi.org/10.1016/j.placenta.2021.09.007 |
| ISSN: | 1532-3102 |
| Popis: | INTRODUCTION: The reported effects of SARS-CoV-2 on pregnancy outcomes are conflicting; studies frequently overlook the placenta, which is critical for the health of the mother and infant(s). This study aimed to determine the effect of pandemic stress ± SARS CoV-2 infection on placental histopathology. METHODS: Women were recruited in Canada (n = 69); France (n = 21) or in the UK (n = 25), between March and October 2020. Historic controls (N = 20) were also included. Placenta and fetal membrane samples were collected rapidly after delivery and were fixed and stained for histopathological analysis. Maternal demographical data and obstetric outcomes were recorded. RESULTS: Over 80% of the placentas from SARS-CoV-2+ pregnancies had histopathological abnormalities: predominantly structural (71-86%) or inflammatory (9-22%), depending on geographical location. Excessive fibrin was seen in all sites, whereas deciduitis (Canada), calcifications (UK), agglutinations and chorangiosis (France) predominated in different locations. The frequency of abnormalities was significantly higher than in SARS-CoV-2 negative women (50%, p |
| Databáze: | OpenAIRE |
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