Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application
| Autor: | Nuggehally R. Srinivas, Muzeeb Syed |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Correlation coefficient
Cmax Administration Oral Zolmitriptan Triptans Models Biological 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Linear regression Statistics medicine Humans Pharmacology (medical) Administration Intranasal Oxazolidinones Randomized Controlled Trials as Topic Sumatriptan business.industry Area under the curve Regression analysis Serotonin 5-HT1 Receptor Agonists Tryptamines Anesthesiology and Pain Medicine Area Under Curve Anesthesia business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Pain & Palliative Care Pharmacotherapy. 30:13-24 |
| ISSN: | 1536-0539 1536-0288 |
| DOI: | 10.3109/15360288.2015.1124165 |
| Popis: | Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a prospective tool for prediction. Using appropriate intranasal pharmacokinetic data, a Cmax vs. AUC relationship was established by linear regression models for sumatriptan and zolmitriptan. The predictions of the AUC values were performed using published mean/median Cmax data and appropriate regression lines. The quotient of observed and predicted values rendered fold-difference calculation. The mean absolute error (MAE), mean positive error (MPE), mean negative error (MNE), root mean square error (RMSE), correlation coefficient (r), and the goodness of the AUC fold prediction were used to evaluate the two triptans. Also, data from the mean concentration profiles at time points of 1 hour (sumatriptan) and 3 hours (zolmitriptan) were used for the AUC prediction. The Cmax vs. AUC models displayed excellent correlation for both sumatriptan (r = .9997; P < .001) and zolmitriptan (r = .9999; P < .001). Irrespective of the two triptans, the majority of the predicted AUCs (83%-85%) were within 0.76-1.25-fold difference using the regression model. The prediction of AUC values for sumatriptan or zolmitriptan using the concentration data that reflected the Tmax occurrence were in the proximity of the reported values. In summary, the Cmax vs. AUC models exhibited strong correlations for sumatriptan and zolmitriptan. The usefulness of the prediction of the AUC values was established by a rigorous statistical approach. |
| Databáze: | OpenAIRE |
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