Delayed-onset dystonia due to perinatal asphyxia: a prospective study
| Autor: | Igor Petrović, Nataša Cerovac, Christine Klein, Vladimir S. Kostic |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Neurological disorder Fetal Distress Cerebral palsy Cohort Studies Pregnancy medicine Humans Cervical dystonia Prospective Studies Prospective cohort study Child Torticollis Dystonia Asphyxia Asphyxia Neonatorum business.industry Cerebral Palsy Infant Newborn medicine.disease Hypotonia Perinatal asphyxia Neurology Anesthesia Apgar Score Female Neurology (clinical) medicine.symptom business |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 22(16) |
| ISSN: | 0885-3185 |
| Popis: | The objective of this work was to establish the existence and incidence of possible delayed-onset dystonia in a cohort of infants with diagnosed perinatal asphyxial hypoxic-ischemic encephalopathy (HIE). This prospective study comprised 103 survivors of perinatal asphyxial HIE, who were regularly followed and neurologically examined in the course of 7 to 13 years after birth (median 10 years). Neurological outcome at the end of the follow-up period was normal in 87 (84.5%) patients, while in 7 (6.8%) only mild neurological signs were detected (behavioral disturbances in 3, clumsiness in 2, and hypotonia in 1 patient). Severe cerebral palsy was diagnosed in nine patients (8.7%). Only one patient was diagnosed with possible delayed-onset segmental dystonia. At the age of 4 years he developed cervical dystonia with spread to one arm in the course of 1.5 years (segmental dystonia) and then stabilized. Other known causes of dystonia, including a DYT1 mutation, were excluded. Our preliminary data suggest that over the course of at least 7 years after birth, approximately 1% of infants who survived perinatal asphyxial HIE would develop delayed-onset dystonia. © 2007 Movement Disorder Society |
| Databáze: | OpenAIRE |
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