Ring closure to beta-turn mimics via copper-catalyzed azide/alkyne cycloadditions
| Autor: | Kevin Burgess, Yu Angell |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Cyclic compound Azides Magnetic Resonance Spectroscopy Molecular Structure Chemistry Stereochemistry Dimer Circular Dichroism Organic Chemistry Molecular Mimicry Molecular Conformation Alkyne Ring (chemistry) Cycloaddition Catalysis chemistry.chemical_compound Cyclization Alkynes Computer Simulation Azide Selectivity Copper |
| Zdroj: | The Journal of organic chemistry. 70(23) |
| ISSN: | 0022-3263 |
| Popis: | [Structure: see text]. Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds indicate that their most favorable conformational states include type I and type II beta-turn conformations. Selectivity for the dimeric products 6 in these cyclization reactions is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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