| Autor: |
Seung Min Baek, Kyung Won Kim, EUN GYUL KIM, Hye Rin Kim, Ji Su Leem, Myung Hyun Sohn, Mi Na Kim |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Allergy, asthmaimmunology research. 14(4) |
| ISSN: |
2092-7355 |
| Popis: |
The prevalence of food allergy, triggered by T-helper type 2 (Th2) cell-mediated inflammation, is increasing worldwide. Interleukin (IL)-18 plays an important role in inflammatory diseases by binding with the IL-18 receptor. IL-18/IL-18 receptor α (IL-18Rα) is a cofactor for immunoglobulin E (IgE) production and Th2 cell development. Studies have not investigated the association between the IL-18/IL-18Rα signaling pathway and food allergy. Here, we investigated the role of IL-18Rα in food allergy induction and development.Wild-type (WT) and IL-18Rα-null mutant (IL-18RαIL-18Rα expression was increased in WT mouse intestines after OVA treatment. Food allergy-induced IL-18RαIL-18Rα regulates allergic reactions and immune responses by regulating T cell responses in food allergies. Moreover, IL-18Rα is involved in the STAT/SOCS signaling pathways. Targeting IL-18Rα signaling might be a novel therapeutic strategy for food allergy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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