Serum FSH level is lower in dysovulating than in ovulating non-PCOS obese women, independently of body mass index
| Autor: | Pascal Pigny, Geoffroy Robin, Didier Dewailly, Sophie Catteau-Jonard, Agathe Dumont, Anne Brunel |
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| Přispěvatelé: | Hôpital Jeanne de Flandre [Lille], École de sages-femmes Baudelocque (ESF Baudelocque), Université Paris Descartes - Paris 5 (UPD5), Gamétogenèse et Qualité du Gamète (GQG), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, Droit et Santé-Université de Lille, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Mucines Epitheliales : du Gene a la Fonction, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Service d'endocrinologie, gynécologie et médecine de la reproduction, Université Paris Descartes - École de sages-femmes Baudelocque (UPD ESF Baudelocque), Gamétogenèse et Qualité du Gamète - ULR 4308 (GQG), Normandie Université (NU)-Normandie Université (NU)-Université de Lille |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Ovulation Femmes obèses Leptin medicine.medical_specialty Serum fsh Adolescent endocrine system diseases Dysovulation Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Body Mass Index 03 medical and health sciences Young Adult BMI 0302 clinical medicine Endocrinology IMC Internal medicine FSH medicine Humans Obesity Menstruation Disturbances Retrospective Studies Leptine 2. Zero hunger business.industry Obese women [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology General Medicine female genital diseases and pregnancy complications 030220 oncology & carcinogenesis Case-Control Studies Ovulation disorder Female Follicle Stimulating Hormone business Body mass index Infertility Female Polycystic Ovary Syndrome |
| Zdroj: | Annales d'Endocrinologie Annales d'Endocrinologie, Elsevier Masson, 2019, 80 (4), pp.225-228. ⟨10.1016/j.ando.2018.11.003⟩ |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2018.11.003⟩ |
| Popis: | The prevalence of ovulation disorder (OD) is 3-fold higher in obese than normal-weight women. Most ODs are associated with concomitant polycystic ovary syndrome (PCOS), but obesity by itself can cause OD, through mechanisms that remain poorly documented. The literature on obese non-PCOS women with OD is sparse. The aim of the present study was to analyze a population of obese non-PCOS women with OD to shed further light on the mechanism of ovulation disorder.This retrospective observational study of infertile obese women without PCOS compared a control group without OD (n=45) to a study group with OD (n=30) (OD group). Clinical, hormonal, and ultrasound characteristics were collected between cycle days 2 and 5. Women older than 37 years and women with PCOM (polycystic ovarian morphology) or hormonal disorder were excluded.Body mass index (BMI) was significantly higher in the OD group, as were waist circumference and insulin and leptin serum levels. Conversely, serum follicle stimulating hormone (FSH) levels were significantly lower. After adjustment for BMI, only serum FSH level remained significantly different between the 2 groups. Discriminant analysis suggested that FSH may have a much stronger effect on OD than BMI.Low serum FSH level may contribute to OD in some obese women, independently of BMI. The pathophysiological mechanism of this finding and its impact on therapeutic strategies must be clarified. |
| Databáze: | OpenAIRE |
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