Chrysotile asbestos in kidney cortex of chronically gavaged rats
| Autor: | K. J. Patel-Mandlik, J. R. Millette |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Kidney cortex Kidney Cortex Asbestos Serpentine Health Toxicology and Mutagenesis Toxicology Dose level medicine.disease_cause Asbestos Dry weight Internal medicine Chrysotile medicine Animals Fiber Pregnancy Dose-Response Relationship Drug Chemistry Age Factors Rats Inbred Strains General Medicine medicine.disease Pollution Rats Endocrinology Regression Analysis Female Length distribution |
| Zdroj: | Archives of environmental contamination and toxicology. 12(2) |
| ISSN: | 0090-4341 |
| Popis: | Using the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. Four groups of rats consisted of ages ranging from 0–200, 200–400, 400–600 and 600–800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fibers recovery being 5.34 × 103/mg dry weight. Average fiber level in control tissues was 0.23 × 103/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (P < 0.005) than that from test tissues. Test groups showed highly significant differences (P < 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 < P < 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall. |
| Databáze: | OpenAIRE |
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