PRINCIPLE: a tool for associating genes with diseases via network propagation
| Autor: | Oded Magger, Roded Sharan, Igor Berman, Assaf Gottlieb, Eytan Ruppin |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Statistics and Probability
Java Computer science business.industry Biochemistry Computer Science Applications World Wide Web Computational Mathematics ComputingMethodologies_PATTERNRECOGNITION Software Documentation Computational Theory and Mathematics Interaction network Humans Disease Genetic Predisposition to Disease Protein Interaction Maps business Molecular Biology Gene computer Algorithms computer.programming_language |
| Zdroj: | Bioinformatics. 27:3325-3326 |
| ISSN: | 1367-4811 1367-4803 |
| DOI: | 10.1093/bioinformatics/btr584 |
| Popis: | Summary: PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein–protein interaction network to genes causing phenotypically similar disorders to the query disease. Availability: Implemented in Java, PRINCIPLE runs over Cytoscape 2.7 or newer versions. Binaries, default input files and documentation are freely available at http://www.cs.tau.ac.il/~bnet/software/PrincePlugin/. Contact:roded@tau.ac.il; assafgot@tau.ac.il |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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