Qualitative and quantitative comparison of flavor chemicals in tobacco heating products, traditional tobacco products and flavoring capsules
| Autor: | Hyun-Hee Lim, Kyeong-Yun Choi, Ho-Sang Shin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Chromatography Chemistry Clinical Biochemistry food and beverages Pharmaceutical Science Capsules Tobacco Products Electronic Nicotine Delivery Systems Analytical Chemistry Flavoring Agents Heating Drug Discovery Tobacco Food science Gas chromatography–mass spectrometry Quantitative analysis (chemistry) Spectroscopy Flavor |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 207 |
| ISSN: | 1873-264X |
| Popis: | A gas chromatography-mass spectrometric (GC-MS) method was developed for the qualitative and quantitative analysis of flavor chemicals in tobacco heating products (THPs), traditional tobacco products (TTPs) and their flavoring capsules. A total of 247 compounds were identified through nontargeted analysis, 151 compounds were selected as target analytes, and the final 302 compounds were selected to develop an analytical method. The lower limits of detection (LOD) of analytes were 0.00074 to 12 mg/kg and their LOD range was wide depending on the presence or absence in the reference cigarette. The precision of the 302 compounds was less than 24.5%, and the accuracy ranged from 80.0-120%. A total 190 flavors and 5 contaminants were determined in 21 THP, 10 TTP, 8 THP capsules and 11 TTP capsules. When comparing the total flavor content of flavors per cigarette, it was in the order of THP capsule > TTP capsule ≫ THP ≫ TTP. The correlations between the 53 cigarette products and 190 flavor compounds were analyzed using PCA. It has been demonstrated that PCA results can be a useful tool in differentiating brands and manufacturers of tobacco products. |
| Databáze: | OpenAIRE |
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