Thalamic mediation of hypoxic respiratory depression in lambs
| Autor: | Brian J. Koos, Lawrence Kruger, Basil O. Ibe, Arezoo Rajaee, Catalina Guerra |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oxygen deprivation Physiology Thalamus Biology Fetal Hypoxia 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Physiology (medical) medicine Animals Respiratory system Feedback Physiological Sheep Pulmonary Gas Exchange Respiration Respiratory center Respiratory Center Hypoxia (medical) Recurrent apnea Oxygen Fetal hypoxia 030104 developmental biology Anesthesia Female medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 310:R586-R595 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Immaturity of respiratory controllers in preterm infants dispose to recurrent apnea and oxygen deprivation. Accompanying reductions in brain oxygen tensions evoke respiratory depression, potentially exacerbating hypoxemia. Central respiratory depression during moderate hypoxia is revealed in the ventilatory decline following initial augmentation. This study determined whether the thalamic parafascicular nuclear (Pf) complex involved in adult nociception and sensorimotor regulation (Bentivoglio M, Balerecia G, Kruger L. Prog Brain Res 87: 53–80, 1991) also becomes a postnatal controller of hypoxic ventilatory decline. Respiratory responses to moderate isocapnic hypoxia were studied in conscious lambs. Hypoxic ventilatory decline was compared with peak augmentation. Pf and/or adjacent thalamic structures were destroyed by the neuron-specific toxin ibotenic acid (IB). IB lesions involving the thalamic Pf abolished hypoxic ventilatory decline. Lesions of adjacent thalamic nuclei that spared Pf and control injections of vehicle failed to blunt hypoxic respiratory depression. Our findings reveal that the thalamic Pf region is a critical controller of hypoxic ventilatory depression and thus a key target for exploring molecular concomitants of forebrain pathways regulating hypoxic ventilatory depression in early development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|