Carcinoma developing in a fibroadenoma in a woman with a family history of breast cancer: a case report and review of literature
| Autor: | Anju Bansal, Chintamani, K Yashwant, Sunita Saxena, Dinesh Bhatnagar, Megha Tandon, Pranjal Kulshreshtha, Tushar Aeron, Rohan Khandelwal |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Medicine(all)
Gynecology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Lumpectomy Case Report General Medicine medicine.disease Malignancy Fibroadenoma body regions Breast cancer medicine Carcinoma Mammography Radiology Family history Breast carcinoma business skin and connective tissue diseases |
| Zdroj: | Cases Journal |
| ISSN: | 1757-1626 |
| Popis: | Introduction Malignant transformation of a fibroadenoma is rare with only about 100 cases reported in the world literature. Fibroadenoma occurring in middle aged woman with a strong family history of breast or ovarian cancer should be investigated with a high suspicion for malignancy. Case presentation A 35-year- old Indian lady operated previously for fibroadenoma of the right breast presented with a recurrent lump at the same site. She had a strong family history of breast carcinoma. Mammography and trucut biopsy was suggestive of infiltrating duct carcinoma. She was managed by lumpectomy and axillary lymph node dissection with a satisfactory outcome. There was no evidence of BRCA-1, BRCA-2 mutation on immunohistochemistry. Conclusion Malignant change in a pre-existing fibroadenoma is rare, however in a middle aged woman with a family history of breast cancer it should be suspected. In the absence of any definite clinical and radiological criteria of diagnosing malignant change in a fibroadenoma, high suspicion index is mandatory. The management and outcome depends on the stage and grade of presentation. |
| Databáze: | OpenAIRE |
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