Resolution of Abnormal Gonadotropin Secretion After Surgical Cure in Men With ACTH-Dependent Cushing Syndrome
| Autor: | Skand Shekhar, Lynnette K. Nieman, Joselyne Tessa Tonelu, Janet E. Hall, Gordon B. Cutler |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class business.industry Endocrinology Diabetes and Metabolism Neuroendocrinology and Pituitary Clinical Advances Hypothalamic–pituitary–gonadal axis Reference range Gonadotropin-releasing hormone medicine.disease Gonadotropin secretion Cushing syndrome Neuroendocrinology and Pituitary Endocrinology Internal medicine medicine Gonadotropin Menotropins business AcademicSubjects/MED00250 hormones hormone substitutes and hormone antagonists Blood sampling |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/jendso/bvab048.1292 |
| Popis: | Background: Hypothalamic-pituitary-gonadal (HPG) dysfunction is known to occur in male patients with Cushing Syndrome (CS) but the underlying mechanisms of HPG dysfunction remain unclear. We performed frequent blood sampling and GnRH stimulation tests to assess gonadotropin secretion in males before and after surgical cure of CS. Methods: We evaluated eight males age 32.5±12 years (mean ± SD) enrolled for surgical cure of ACTH-dependent CS at a tertiary care research center. Urinary free cortisol (UFC) was measured before and after surgery. Blood was sampled every 20 minutes for 24-hours with measurement of LH and FSH, before and 2 weeks to 160 weeks (median 80 weeks) after surgery. Patients received 100 μg of gonadotropin releasing hormone (GnRH) iv with measurement of LH and FSH at 0, 10 and 20 min before and 15, 30, 45, 60, 120 and 180 min after administration. Non-normative data was log-transformed before analysis using paired two-tail t-tests. A p-value of |
| Databáze: | OpenAIRE |
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