Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling
| Autor: | Christine Prejean, Oscar R. Colamonici |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Janus kinase 1 medicine.medical_treatment Membrane Proteins Alpha interferon Janus Kinase 1 Receptor Interferon alpha-beta Protein-Tyrosine Kinases Biology Cell biology Cytokine Interferon Immunology medicine Animals Humans Phosphorylation Signal transduction Interferon alfa Interferon type I Receptors Interferon Signal Transduction medicine.drug Interferon regulatory factors |
| Zdroj: | Seminars in Cancer Biology. 10:83-92 |
| ISSN: | 1044-579X |
| DOI: | 10.1006/scbi.2000.0311 |
| Popis: | Type I interferons are imperative in maintaining a defense against viral infection. These cytokines also play an important role in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. In the present article, we attempt to analyze the advances made in the last four years on type I interferon signaling. This review will focus on the contribution of the cytoplasmic domain of the alpha and betaL chains of the receptor to the activation of the Jak-Stat pathway. We also analyze the possible role of other pathways in interferon signaling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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