Enhancement of mRNA Synthesis from Marek's Disease Virus Genome in the Lymphoblastoid Cell Line, MDCC-MSB1, by 5-Azacytidine
| Autor: | Masanobu Hayashi, Tatsuya Furuichi, Shigeo Namioka, Shaomin Ren, Meihan Nonoyama, Emiko Isogai |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
animal structures
Transcription Genetic animal diseases viruses Restriction Mapping Gene Expression Genome Viral Biology Genome Virus Cell Line chemistry.chemical_compound immune system diseases Transcription (biology) hemic and lymphatic diseases Animals Lymphocytes RNA Messenger Herpesvirus 2 Gallid Psychological repression Messenger RNA Marek's disease General Veterinary Methylation biology.organism_classification Virology Molecular biology chemistry DNA Viral Azacitidine RNA Poly A DNA |
| Zdroj: | Journal of Veterinary Medical Science. 56:287-291 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.56.287 |
| Popis: | Marek's disease virus (MDV) DNA in latently infected lymphoblastoid cell lines is considerably methylated. A treatment of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB1), with 5-azacytidine (5-AzC) resulted in a hypomethylation of MDV DNA and an increase in mRNA from certain portions of the MDV DNA. These results suggest methylation of MDV DNA as being one of the factors associated with a repression of transcription of MDV DNA in the lymphoblastoid cell line, MSB1. |
| Databáze: | OpenAIRE |
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