Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras
| Autor: | Nicolas Dupin, Stéphane Bretagne, Jean-michel Molina, Willy Rozenbaum, Eric Dannaoui, Anne-Lise Bienvenu, Sophie Matheron, Cedric Arvieux, Stéphane Ranque |
|---|---|
| Přispěvatelé: | Service de réanimation médicale [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Mycologie moléculaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire ( CNRMA ), Institut Pasteur [Paris], Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service de Médecine Interne, GH Bichat-Claude Bernard, Paris, Centre de Référence Déficits Immunitaires Héréditaires ( CEREDIH ), Centre d'infectiologie Necker-Pasteur [CHU Necker], Thérapeutique Recombinante Expérimentale ( TIMC-IMAG-THEREX ), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire (CNRMA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut Pasteur [Paris], Thérapeutique Recombinante Expérimentale (TIMC-IMAG-TheREx), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP] |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Antifungal Agents MESH : Retrospective Studies MESH : Immune Reconstitution Inflammatory Syndrome MESH: Antiretroviral Therapy Highly Active 0302 clinical medicine Immune Reconstitution Inflammatory Syndrome immune system diseases Antiretroviral Therapy Highly Active MESH: Histoplasmosis MESH : Female 030212 general & internal medicine Young adult MESH: Anti-HIV Agents Histoplasmosis [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology 0303 health sciences MESH : AIDS-Related Opportunistic Infections MESH: Middle Aged MESH : Prognosis MESH: AIDS-Related Opportunistic Infections Mortality rate MESH : Acquired Immunodeficiency Syndrome Highly active anti-retroviral therapy virus diseases Articles Middle Aged MESH : Adult Prognosis 3. Good health Infectious Diseases MESH: Young Adult MESH: Immune Reconstitution Inflammatory Syndrome Female France Adult medicine.medical_specialty Anti-HIV Agents AIDS-Related Opportunistic Infections MESH : Male MESH : Antifungal Agents MESH : Young Adult MESH: Prognosis 03 medical and health sciences Young Adult Immune reconstitution inflammatory syndrome Acquired immunodeficiency syndrome (AIDS) MESH : Histoplasmosis Virology Internal medicine medicine Humans MESH : Middle Aged MESH : France Retrospective Studies MESH: Acquired Immunodeficiency Syndrome Acquired Immunodeficiency Syndrome MESH: Humans 030306 microbiology business.industry MESH : Anti-HIV Agents MESH : Humans Retrospective cohort study MESH: Retrospective Studies MESH: Adult medicine.disease MESH: Antifungal Agents MESH : Antiretroviral Therapy Highly Active MESH: Male MESH: France Immunology Parasitology business MESH: Female |
| Zdroj: | American Journal of Tropical Medicine and Hygiene American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2011, 85 (5), pp.934-41. 〈10.4269/ajtmh.2011.11-0224〉 American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2011, 85 (5), pp.934-41. ⟨10.4269/ajtmh.2011.11-0224⟩ American Journal of Tropical Medicine and Hygiene, 2011, 85 (5), pp.934-41. ⟨10.4269/ajtmh.2011.11-0224⟩ |
| ISSN: | 0002-9637 |
| DOI: | 10.4269/ajtmh.2011.11-0224〉 |
| Popis: | International audience; Histoplasma capsulatum var. capsulatum infection is rare outside disease-endemic areas. Clinical presentation and outcome of acquired immunodeficiency syndrome-related histoplasmosis are unknown in non-endemic areas with wide access to highly active anti-retroviral therapy (HAART). Retrospective analysis of cases recorded at the French National Reference Center for Mycoses and Antifungals during two decades: pre-HAART (1985-1994) and HAART (1997-2006). Clinical features and outcome of all adults with proven acquired immunodeficiency syndrome-related histoplasmosis were compared between the two periods. One hundred four patients were included (40 during the pre-HAART era and 64 during the HAART era). Diagnosis was established a mean of 62 days after onset of symptoms. One-year overall mortality rates decreased from 53% (pre-HAART era) to 22% (HAART era). Diagnosis during the pre-HAART era and an older age were the only independent factors associated with death. Histoplasmosis is a rare invasive fungal infection outside disease-endemic areas. Its prognosis improved significantly during the HAART era. |
| Databáze: | OpenAIRE |
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