Low blood pressure and antihypertensive treatment are independently associated with physical and mental health status in patients with arterial disease: the SMART study
| Autor: | Mirjam I. Geerlings, Majon Muller, Frank L.J. Visseren, Anne M. Grool, Y. van der Graaf, Hadassa M. Jochemsen, Lenore J. Launer |
|---|---|
| Přispěvatelé: | Internal medicine, Neurology, ICaR - Circulation and metabolism, NCA - neurodegeneration |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Health Status Population Arterial Occlusive Diseases Asymptomatic Article Coronary artery disease Risk Factors Surveys and Questionnaires Internal medicine Internal Medicine medicine Humans Antihypertensive drug education Antihypertensive Agents Aged Netherlands Aged 80 and over education.field_of_study business.industry Confounding Middle Aged medicine.disease Mental health Confidence interval Treatment Outcome Blood pressure Hypertension Linear Models Physical therapy Female Hypotension medicine.symptom business |
| Zdroj: | Muller, M, Jochemsen, H M, Visseren, F L J, Grool, A M, Launer, L J, van der Graaf, Y & Geerlings, M I 2013, ' Low blood pressure and antihypertensive treatment are independently associated with physical and mental health status in patients with arterial disease: the SMART study ', Journal of Internal Medicine, vol. 274, no. 3, pp. 241-251 . https://doi.org/10.1111/joim.12069 Journal of Internal Medicine, 274(3), 241-251. Wiley-Blackwell |
| ISSN: | 0954-6820 |
| DOI: | 10.1111/joim.12069 |
| Popis: | Objective To investigate the independent effects of antihypertensive treatment and blood pressure (BP) levels on physical and mental health status in patients with arterial disease. Design and setting Cross-sectional analyses were conducted within the single-centre Secondary Manifestations of ARTerial disease (SMART) study, in a hospital care setting. Subjects A total of 5877 patients (mean age 57 years) with symptomatic and asymptomatic arterial disease underwent standardized vascular screening. Main outcome measure The primary outcome was self-rated physical and mental health assessed using the 36-item short-form health survey. Results In the total population, antihypertensive drug use and increased intensity of antihypertensive treatment were associated with poorer health status independent of important confounders including BP levels; adjusted mean differences [95% confidence interval (CI)] in physical and mental health between n = 0 and n ≥ 3 antihypertensives were −1.2 (−2.1; −0.3) and −3.5 (−4.4; −2.6), respectively. Furthermore, both lower systolic and lower diastolic BP levels were related to poorer physical and mental health status independent of antihypertensive treatment. Mean differences (95% CI) in physical and mental health status per SD decrease in systolic BP were −0.56 (−0.84; −0.27) and −0.32 (−0.61; −0.03) and per SD decrease in diastolic BP were −0.50 (−0.78; −0.23) and −0.08 (−0.36; 0.20), respectively. The association between low BP and poor health status was particularly present in patients with coronary artery disease. Conclusions In a population of patients with asymptomatic and symptomatic arterial disease, antihypertensive treatment and lower BP levels are independently associated with poorer self-rated physical and mental health. These findings suggest that different underlying mechanisms may explain these independent associations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text