The impact of intrauterine and extrauterine weight gain in premature infants on later body composition
| Autor: | Jesús Argente, Gabriel Á. Martos-Moreno, Mary Fewtrell, Miriam Martínez-Biarge, Rosario Madero, Laura Álvarez-Cuervo, Vicente Barrios, Izaskun Dorronsoro, J. Coya, Miguel Saenz de Pipaon, Nancy F. Butte, José Quero |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male Birth weight Physiology 030209 endocrinology & metabolism Gestational Age Weight Gain 03 medical and health sciences 0302 clinical medicine Insulin resistance Absorptiometry Photon Child Development 030225 pediatrics Medicine Birth Weight Humans Infant Very Low Birth Weight Insulin Prospective Studies Adiposity business.industry Postmenstrual Age Age Factors Infant Newborn Gestational age Infant medicine.disease Low birth weight Postnatal age Child Preschool Pediatrics Perinatology and Child Health Small for gestational age Female medicine.symptom Insulin Resistance business Weight gain Biomarkers Infant Premature |
| Zdroj: | Pediatric research. 82(4) |
| ISSN: | 1530-0447 |
| Popis: | BackgroundThe impact of intrauterine and extrauterine growth on later insulin resistance and fat mass (FM) in very low birth weight (VLBW) infants is not well established. The aim of our study was to evaluate the effects of intrauterine and early/late extrauterine growth on later insulin resistance and body composition in VLBW infants from 6 months' corrected age (CA) to 36 months.MethodsProspective measurements of body composition by dual-energy X-ray absorptiometry and insulin resistance by homeostasis model assessment insulin resistance (HOMA-IR) along with other fasting plasma biochemistries were made in 95 VLBW infants at 6, 12, 18, and 24 months' CA and 36 months' postnatal age. Mixed-effect models were used to evaluate the effects of age, sex, maturation status, and Δweight SD score on percentage FM (PFM), FM index (FMI), fat-free mass index (FFMI), and HOMA-IR.ResultsPFM and FMI were negatively associated with a decrease in weight-SD scores from birth to 36 weeks' postmenstrual age (PMA; P=0.001) and from 36 weeks' PMA to 6 months' CA (P=0.003). PFM and FMI were higher in AGA than in small for gestational age (SGA) infants. HOMA-IR was not associated with the Δweight-SD scores in either period.ConclusionsCatch-down growth in terms of weight is associated with persistently lower adiposity but not insulin resistance up to 36 months of age. |
| Databáze: | OpenAIRE |
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