Nitric oxide in the medial prefrontal cortex contributes to the acquisition of cocaine place preference and synaptic plasticity in the laterodorsal tegmental nucleus
| Autor: | Hironori Kamii, Masabumi Minami, Katsuyuki Kaneda, Naofumi Taoka |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Tegmentum Mesencephali Dopamine Conditioning Classical Drug-Seeking Behavior Prefrontal Cortex Addiction Nitric Oxide Synthase Type I Nitric Oxide Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cocaine Neuroplasticity medicine Animals Cholinergic neuron Neurotransmitter Prefrontal cortex Neuronal Plasticity Nitric oxide synthase musculoskeletal neural and ocular physiology General Neuroscience Laterodorsal tegmental nucleus Medial prefrontal cortex Cholinergic Neurons Conditioned place preference 030104 developmental biology medicine.anatomical_structure nervous system chemistry Synaptic plasticity Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience Letters. 660:39-44 |
| ISSN: | 0304-3940 |
| Popis: | 金沢大学医薬保健研究域薬学系 Nitric oxide (NO), a gaseous neurotransmitter, is involved in a variety of brain functions, including drug addiction. Although previous studies have suggested that NO plays an important role in the development of cocaine addiction, the brain region(s) in which NO acts and how it contributes to cocaine addiction remain unclear. In this study, we examined these issues using a cocaine-induced conditioned place preference (CPP) paradigm and ex vivo electrophysiological recordings in rats. Specifically, we focused on the medial prefrontal cortex (mPFC) and laterodorsal tegmental nucleus (LDT), brain regions associated with cocaine CPP development and cocaine-induced plasticity. Intra-mPFC injection of the non-selective NO synthase (NOS) inhibitor L-NAME or the neuronal NOS (nNOS) selective inhibitor L-NPA during the conditioning phase disrupted cocaine CPP. Additionally, intra-mPFC injection of L-NPA prior to each cocaine injection prevented the induction of presynaptic plasticity, induced by repeated cocaine administration, in LDT cholinergic neurons. These findings indicate that NO generated in the mPFC contributes to the acquisition of cocaine CPP and the induction of neuroplasticity in LDT cholinergic neurons. Together with previous studies showing that NO induces membrane plasticity in mPFC neurons, that mPFC neurons project to the LDT, and that LDT activity is critical for the acquisition of cocaine CPP, the present findings suggest that NO-mediated neuroplasticity induced in the mPFC-LDT circuitry is critical for the development of cocaine addiction. © 2017 Elsevier B.V. Embargo Period 12 months |
| Databáze: | OpenAIRE |
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