Stereoselective Construction of Tertiary Homoallyl Alcohols and Ethers by Nucleophilic Substitution at Quaternary Carbon Stereocenters

Autor:	Xu Chen, Kaushalendra Patel, Ilan Marek
Rok vydání:	2022
Předmět:	General Chemistry General Medicine Catalysis
Zdroj:	Angewandte Chemie. 135
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.202212425
Popis:	An efficient method for the stereoselective construction of tertiary C-O bonds via a stereoinvertive nucleophilic substitution at the quaternary carbon stereocenter of cyclopropyl carbinol derivatives using water, alcohols and phenols as nucleophiles has been developed. This substitution reaction proceeds under mild conditions and tolerates several functional groups, providing a new access to the stereoselective formation of highly congested tertiary homoallyl alcohols and ethers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c3ee5c6d9c22ae3702ecbaddb8a8a6 https://doi.org/10.1002/ange.202212425 Zobrazit plný text záznamu Plný text