Renal Function Recovery with Total Artificial Heart Support
| Autor: | Inna Tchoukina, Richard H. Cooke, Vigneshwar Kasirajan, Gundars J. Katlaps, Melissa C. Smallfield, Adam M. Goodreau, Luke G. Wolfe, Mohammed A. Quader, Keyur B. Shah |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Biophysics Urology Renal function Bioengineering Heart Artificial 030204 cardiovascular system & hematology urologic and male genital diseases law.invention Biomaterials 03 medical and health sciences 0302 clinical medicine law Artificial heart medicine Humans In patient 030212 general & internal medicine Renal Insufficiency Dialysis Heart Failure business.industry General Medicine Recovery of Function Middle Aged medicine.disease Heart failure Concomitant Female Hemodialysis business |
| Zdroj: | ASAIO journal (American Society for Artificial Internal Organs : 1992). 62(1) |
| ISSN: | 1538-943X |
| Popis: | Heart failure patients requiring total artificial heart (TAH) support often have concomitant renal insufficiency (RI). We sought to quantify renal function recovery in patients supported with TAH at our institution. Renal function data at 30, 90, and 180 days after TAH implantation were analyzed for patients with RI, defined as hemodialysis supported or an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m. Between January 2008 and December 2013, 20 of the 46 (43.5%) TAH recipients (age 51 ± 9 years, 85% men) had RI, mean preoperative eGFR of 48 ± 7 ml/min/1.73 m. Renal function recovery was noted at each follow-up interval: increment in eGFR (ml/min/1.73 m) at 30, 90, and 180 days was 21 ± 35 (p = 0.1), 16.5 ± 18 (p = 0.05), and 10 ± 9 (p = 0.1), respectively. Six patients (30%) required preoperative dialysis. Of these, four recovered renal function, one remained on dialysis, and one died. Six patients (30%) required new-onset dialysis. Of these, three recovered renal function and three died. Overall, 75% (15 of 20) of patients' renal function improved with TAH support. Total artificial heart support improved renal function in 75% of patients with pre-existing significant RI, including those who required preoperative dialysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|