Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent
| Autor: | Leonie J. M. Mekenkamp, Bauke Ylstra, Cornelis J. A. Punt, Patricia van Cleef, Hendrik F. van Essen, Danielle Israeli, Iris D. Nagtegaal, Gerrit A. Meijer, Josien C. Haan, Jeroen R. Dijkstra |
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| Přispěvatelé: | Pathology, CCA - Disease profiling, CCA -Cancer Center Amsterdam, Oncology |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Male Pathology Colorectal cancer Microarrays High resolution lcsh:Medicine Metastasis Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2] Databases Genetic Basic Cancer Research Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] Chromosomes Human Neoplasm Metastasis lcsh:Science Multidisciplinary Chromosome Biology Colon Adenocarcinoma Genomics Middle Aged Recurrent event medicine.anatomical_structure Medicine Female Colorectal Neoplasms Sequence Analysis Research Article Adult medicine.medical_specialty DNA Copy Number Variations Ovary Biology Rectal Cancer Internal medicine Gastrointestinal Tumors medicine Humans Copy number aberration Aged Chromosome Aberrations lcsh:R Computational Biology Cancers and Neoplasms medicine.disease Large cohort lcsh:Q Comparative genomic hybridization |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 2, p e86833 (2014) PLoS ONE, 9(2):e86833. Public Library of Science PLoS One, 9 PLoS One, 9, 2 Mekenkamp, L J M, Haan, J C, Israeli, D, van Essen, H F B, Dijkstra, J R, van Cleef, P, Punt, C J A, Meijer, G A, Nagtegaal, I D & Ylstra, B 2014, ' Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent ', PLoS ONE, vol. 9, no. 2, e86833 . https://doi.org/10.1371/journal.pone.0086833 PLoS ONE, 9(2). Public Library of Science |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0086833 |
| Popis: | Contains fulltext : 127561.pdf (Publisher’s version ) (Open Access) The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent. |
| Databáze: | OpenAIRE |
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