Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin
| Autor: | Himadri Dinda, Raja Shunmugam, Jayasri Das Sarma, Sayantani Bhattacharya, Mutyala Naidu Ganivada |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility General Chemical Engineering Acylhydrazine 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biodegradable polymer Controlled release Article 0104 chemical sciences lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry PEG ratio Polymer chemistry Copolymer Nanocarriers 0210 nano-technology Caprolactone |
| Zdroj: | ACS Omega ACS Omega, Vol 1, Iss 1, Pp 108-117 (2016) |
| ISSN: | 2470-1343 |
| DOI: | 10.1021/acsomega.6b00018 |
| Popis: | Pendent functionalization of biodegradable polymers provides unique importance in biological applications. In this work, we have synthesized a polymeric nanocarrier for the controlled release of the anticancer drug doxorubicin (DOXI). Inspired by the pH responsiveness of acylhydrazine bonds along with the interesting self-assembly behavior of amphiphilic copolymers, this report delineates the development of a PEG-SS-PCL-DOXI copolymer consisting of DOXI, PEG, and a caprolactone backbone. First, the inclusion of a PEG moiety in the copolymer helps to achieve biocompatibility and aqueous solubility as well as a prolonged circulation time of the nanocarrier. Second, an acid-sensitive acylhydrazine-based linkage is chosen to attach DOXI to trigger sustained drug release, whereas the inclusion of an enzymatically cleavable disulfide linkage in the backbone adds to the advantage of backbone biodegradability at the intracellular level. |
| Databáze: | OpenAIRE |
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