Neuropsychological function in unmedicated recurrent brief depression
| Autor: | Ulrik Fredrik Malt, Stein Andersson, H. Lövdahl |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Bipolar Disorder Psychometrics Comorbidity Neuropsychological Tests Verbal learning Recurrent brief depression Executive Function Recurrence medicine Reaction Time Verbal fluency test Humans Effects of sleep deprivation on cognitive performance Psychomotor learning Depressive Disorder medicine.diagnostic_test Neuropsychological test medicine.disease Psychiatry and Mental health Clinical Psychology Mood Hypomania Memory Short-Term Female medicine.symptom Psychology Cognition Disorders Clinical psychology |
| Zdroj: | Journal of affective disorders. 125(1-3) |
| ISSN: | 1573-2517 |
| Popis: | Background Recurrent brief depression (RBD) is a mood disorder characterized by mild to severe depressive episodes lasting less than 2 weeks and occurring approximately once a month with complete recovery between episodes. The aim of this study was to describe neuropsychological impairments associated with RBD, relating cognitive performance to clinical features and comorbidity. Methods Forty-six ICD-10 defined RBD patients (mean age 33.8) and 24 matched controls were assessed on working memory/attention tasks, executive functions, verbal/visual memory, and psychomotor speed. Results Patients were significantly impaired across all domains of cognition except for verbal learning and non-semantic verbal fluency. Neuropsychological performance was not related to depression severity, duration of depressive episodes, interval duration, psychiatric or somatic comorbidity, or attributable to a general reduction in processing speed or effort. Patients reporting previous major depressive episodes were impaired on one measure of psychomotor speed. Previous episodes of hypomania were not related to neuropsychological performance. Limitations The relatively high number of self-referrals, high female-to-male ratio in the patient sample, and the relatively high level of education and intellectual capacity among participants may limit the possibility to generalize our results to the RBD population in general. Conclusions Unmedicated RBD patients demonstrate significant neuropsychological impairment that also may persist into euthymic states. Examining cognitive functions might be equally important in RBD as in major depression with consequences for functional diagnostics and treatment strategies. |
| Databáze: | OpenAIRE |
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