Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
| Autor: | Bin Xue, Vrushank Davé, Vladimir N. Uversky, Ravi Ramesh Pathak, Elisabeth R. M. Tillier, Alexandr Bezginov, Jaymin J. Kathiriya |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Multidisciplinary Focal adhesion Kinase-1 Kinase Biology lcsh:Computer applications to medicine. Medical informatics Cell biology Evolution of intrinsically disordered regions 03 medical and health sciences 030104 developmental biology Protein kinase domain Protein kinases Cytoskeletal remodeling Posttranslational modification lcsh:R858-859.7 Kinome lcsh:Science (General) Cytoskeleton Data Article lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 10, Iss C, Pp 315-324 (2017) Data in Brief |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2016.11.099 |
| Popis: | We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase domains (KDs) and kinases as a whole protein (WP) are reported. Further, we have reported its post translational modifications of FAK1 IDRs and their contribution to the cytoskeletal remodeling. We also report the data to build a protein-protein interaction (PPI) network of primary and secondary FAK1-interacting hybrid proteins. Detailed analysis of the data and its effect on FAK1-related functions have been described in “Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling” (Kathiriya et. al., 2016) [1]. |
| Databáze: | OpenAIRE |
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