Artesunate/Amodiaquine-Induced Acute Extrapyramidal Reactions in Children and Younger Adults: Case Series Assessment
| Autor: | Dawit Tesfai, Selamawit Ghebrehiwet, Mulugeta Russom, Iyassu Bahta, Selam Mihreteab, Gelila Abrham, Semere Gebregiorgis, Abdulmumini Usman, Elsa Mekonnen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
Adult Male Pediatrics medicine.medical_specialty Time Factors Adolescent media_common.quotation_subject 030231 tropical medicine Pharmacology toxicology Amodiaquine Toxicology 03 medical and health sciences chemistry.chemical_compound Antimalarials Pharmacovigilance Young Adult 0302 clinical medicine Basal Ganglia Diseases Medicine Humans Pharmacology (medical) 030212 general & internal medicine Drug reaction Child media_common Pharmacology Dose-Response Relationship Drug business.industry Artesunate/amodiaquine Age Factors Middle Aged Artemisinins Hospitalization Drug Combinations chemistry Younger adults Artesunate Female Drug Overdose business medicine.drug |
| Zdroj: | Drug safety. 39(8) |
| ISSN: | 1179-1942 |
| Popis: | Several studies conducted in African countries reported the artesunate and amodiaquine (AS/AQ) tablet as a safe and well-tolerated anti-malarial drug in children and younger adults. The aim of this case series assessment was to assess the causal relationship between the AS/AQ tablet and extrapyramidal reactions in children and younger adults and to investigate the factor(s) predisposing to the adverse drug reactions.The causal relationship of all the cases was first assessed individually using the Naranjo Probability Scale and then subjected to a case series assessment using Austin Bradford-Hill criteria.A total of 43 acute extrapyramidal reactions associated with the AS/AQ tablet were reported between 2012 and 16 November, 2015 to the Eritrean Pharmacovigilance Centre. The causality was found to be probable or highly probable for 33 (76.7 %) of the cases and the rest (10; 23.3 %) of the cases had a possible causal association. The extrapyramidal reactions had more or less similar clinical features in most of the cases and were characterized by abnormal involuntary contractions of muscles. The median age and body weight of the cases were 15 years and 40 kg, respectively, and 70 % of them were males. 90.7% of the reactions manifested in children and younger adults (aged26 years). In most of the cases, reactions manifested in the third day from the start of treatment and 88.3 % of cases were hospitalized.The causal relationship between the AS/AQ tablet and extrapyramidal reactions in children and younger adults was found to be apparent and possibly owing to dose accumulation or an overdose of amodiaquine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink