Mucopolysaccharidosis VII in a Cat
| Autor: | D. A. Wenger, Mary Anna Thrall, Patricia C. Schultheiss, J. M. Owens, S. A. Gardner |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty 040301 veterinary sciences Mucopolysaccharidosis Tentorium cerebelli Connective tissue Mucopolysaccharidosis VII Cat Diseases 0403 veterinary science 03 medical and health sciences Fatal Outcome Temporal bone medicine Animals Abnormalities Multiple Rib cage General Veterinary business.industry 04 agricultural and veterinary sciences Anatomy medicine.disease Hypoplasia Microscopy Electron Skull 030104 developmental biology medicine.anatomical_structure Connective Tissue Cats Lysosomes business |
| Zdroj: | Veterinary Pathology. 37:502-505 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1354/vp.37-5-502 |
| Popis: | Mucopolysaccharidosis VII was diagnosed in a domestic shorthair cat from California. The cat was small and had multiple abnormalities, including a small body disproportionate to the size of the skull, angular deformities of the ribs, abnormally short forelimbs, luxating patellas, generalized epiphyseal dysplasia involving the vertebrae and long bones, cuboidal vertebrae, pectus excavatum, subluxation of both hips, osteosclerosis of the tentorium cerebelli and left petrous temporal bone, tracheal hypoplasia, and corneal clouding. b-Glucuronidase activity was markedly decreased in peripheral blood leukocytes. The cat died at 21 months of age, and a complete necropsy was performed. Tissues were examined by light and transmission electron microscopy. Large clear, round vacuoles representing distended lysosomes were present in many epithelial and connective tissue cells, including fibrocytes, chondrocytes, smooth muscle cells, hepatocytes, astrocytes, and macrophages. |
| Databáze: | OpenAIRE |
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